[대학원 생명과학과 세미나 안내]
연사 : 오병하 교수(KAIST, 생명과학과)
연제 : Computational protein design and its applications
일시 : 2021년 04월 30일 (금) 오후 5시
장소 : 온라인 화상 강의로 진행됩니다.
초청교수 : 우재성 교수
Abstract
In the endless protein fold space, nature has sampled only a “spot” of the space. Protein design with the ROSETTA software suite enables sampling of enormous protein fold space that has not been explored by nature. Since the function of a protein is determined by the three-dimensional structure of the protein, billions of new proteins with a novel function, in principle, can be generated by designing new protein folds. I will introduce a number of examples of de novo protein design and protein-protein interface design by this computational approach with aims to create novel proteins for therapy or diagnosis. I will also discuss computational monoclonal antibody design, which explores the amino acid sequences of the ‘complementary determining regions’ of antibodies that are hardly accessible by conventional library search or in vivo hyper mutations.