[대학원 생명과학과 세미나 안내]
연사 : 박성규 교수(GIST 생명과학부)
연제 : Myeloid-derived suppressor cells are controlled by regulatory T cells via TGF-beta during murine colitis
일시 : 2017년 3월 3일 (금) 오후 4시
장소 : 하나과학관 A동 109호
초청교수 : 김충호 교수
Abstract
Myeloid-derived suppressor cells (MDSCs) are well-known regulators of regulatory T-cells (Treg cells); however, the inverse relationship, direct regulation of MDSCs by Treg cells, has not been studied well. Here, we found that colitis due to functional deficiency of Treg cells leads to altered expansion and reduced function of MDSCs. In addition, during differentiation of MDSCs in vitro from bone marrow cells, Treg cells enhance MDSC function and control their differentiation in a mechanism involving TGF-β. Moreover, TGF-β-deficient Treg cells were not able to regulate MDSC function in an experimentally-induced model of colitis. Finally, we evaluated therapeutic effect of TGF-b-mediated in vitro differentiated MDSCs on colitis. Adoptive transfer of MDSCs that had differentiated in the presence of TGF-β was more capable of preventing colitis than the transfer of those MDSCs that differentiated without TGF-β in an experimentally-induced colitis. In conclusion, our results demonstrate a novel interaction between Treg cells and MDSCs that contributes to regulation of MDSC proliferation and subsequent acquisition of immunosuppressive functions.