[대학원 생명과학과 세미나 안내]
연사 : 박보연 교수(연세대 시스템생물학과)
연제 : Key regulators in cytokine RNA metabolism during infections
일시 : 2016년 11월 11일 (금) 오후 4시
장소 : 하나과학관 A동 109호
초청교수 : 최의주 교수
Abstract
The process of RNA synthesis and splicing of cytokine genes is an essential step for activating effective host defense against microbial invaders, thus dysregulation of cytokine expression causes chronic infection conditions or inflammatory diseases. Here, we report that cellular nucleic acid-binding protein (CNBP) acts as a transcription factor that is required for activating the innate immune response. In particular, CNBP selectively bound to specific regulatory elements on the promoter region of inflammatory genes, leading to their maximal production. We also demonstrate that a subnuclear body called the interleukin-6 (IL-6) splicing activating compartment (InSAC) is a nuclear site of IL-6 RNA splicing and stability. Tat-activating regulatory DNA-binding protein-43 (TDP-43) functions as an InSAC scaffold that selectively associates with IL-6 RNAs in a sequence-specific manner. The interaction of TDP-43 with spliceosomal components from the Cajal body leads to the formation of InSAC. Thus, we propose that inflammatory RNA production by CNBP and InSAC represents a new process to control the quality of inflammatory cytokine gene expression and to maintain immune activation during infections.