[대학원 생명과학과 금요세미나 안내]
연사 : 류충민 박사(한국생명공학연구원 슈퍼박테리아연구센터)
연제 : Kingdom barrier를 넘어서: 식물병원균은 동물에 병을 낼 수 있을까? 그리고 그 반대는?
일시 : 2016년 4월 8일 (금) 오후 4시
장소 : 하나과학관 A동 109호
초청교수 : 김옥매 교수
Abstract
Animal and plant pathogenic bacteria have established virulence factors to successfully exploit their respective hosts. Out of the bacteria, Pseudomonas syringae injects a large repertoire of effector proteins into plant cells through a type III secretion apparatus and suppresses immunity in a host-dependent fashion. Here, we firstly demonstrate that P. syringaeinoculation caused mouse fatality in a type III secretion-dependent manner. Effector screening revealed that the HopQ1 disrupted phagocytosis by attenuating the plasticity of actin rearrangement following translocation. A major regulator for actin plasticity, LIM kinase as a molecular target was malfunctioned by directly interacting to its LIM domain with HopQ1. Our results provide new insight into cross-kingdom pathogenic bacteria from plant to animal through disrupting innate immunity by type III effector –based common virulent mechanism.