연사 : 김혜영 교수 (서울대 의대)
연제 : The role of innate lymphoid cells in the development of asthma
일시 : 2015년 6월 5일 (금) 오후 4시
장소 : 하나과학관 A동 109호
초청교수 : 김태성 교수
Abstract
Asthma is a complex and heterogeneous disease, with several phenotypes, including an allergic asthma phenotype, characterized by Th2 cytokine production and associated with allergen sensitization and adaptive immunity. Asthma also includes non-allergic asthma phenotypes that require innate rather than adaptive immunity. These innate pathways to asthma involve macrophages, neutrophils as well as innate lymphoid cells, new described cell types that produce a variety of cytokines, including IL-5, IL-13 and IL-17.
In the allergic disease and asthma, the studies of ILCs have opened a new area of investigation. ILCs are thought a main producer of effector cytokines such as IL-5, IL-9, IL-13, IL-17 and IL-22 which are involved the development of different forms of asthma. Especially ILC2 cells play very important roles in the development of asthma by producing large amount of type 2 cytokines (IL-5, IL-9, and IL-13) in response to IL-25, IL-33 and TSLP. In addition, ILC3s, at least under the obsess situation seem to play critical role in inducing asthma by secreting IL-17 in response to IL-1β.
Since ILCs are important therapeutic targets in several aspects, further investigation of this particular cell subset will open new ways in targeting many unresolved diseases