[대학원 생명과학과 세미나 안내]
연사 : 강찬희 교수(서울대학교 생명과학부)
연제 : Metabolic Control of Senescence from the Perspective of Lysosome
일시 : 2022년 11월 18일 (금) 오후 4시 30분
장소 : 하나과학관 A동 109호
초청교수 : 김충호 교수
Abstract
Aging is the most important single risk factor for numerous chronic human diseases, including neurodegenerative disorders, metabolic syndrome, and cancer. Targeting the fundamental process of aging might therefore be a better strategy for enhancing human health than targeting each chronic disease individually. Although much should be achieved for completely understanding the biological basis of aging, cellular senescence is considered a crucial contributor to organismal aging via two independent but not mutually exclusive mechanisms: (1) stem cells exhaustion and (2) senescence-associated secretory phenotype (SASP) that causes chronic inflammation and tissue dysfunction. Much effort has been recently made to therapeutically target detrimental effects of senescence, including selectively eliminating senescent cells (senolytics) and modulating a proinflammatory senescent secretome (senostatics or senomorphics). Here, I will discuss the current progress and limitations in developing and applying senolytics and senostatics, and present how to improve these crucial strategies for healthy aging by leveraging a unique metabolic feature of senescence stemming from the lysosome.