[대학원 생명과학과 세미나 안내]
연사 : 김혜영 교수(서울대학교 의과대학/의과학과)
연제 : New players in asthma
; Innate lymphoid cells and SiglecF expressing neutrophils.
일시 : 2022년 09월 16일 (금) 오후 4시 30분
장소 : 하나과학관 A동 109호
초청교수 : 최해웅 교수
Abstract
Innate lymphoid cells (ILCs) are a population of tissue-resident innate lymphocytes that are critical mediators of mucosal immunity in many tissues, including the lung and gut. ILCs are particularly abundant at the mucosal barriers, where they are exposed to allergens, commensal microbes, and pathogens. Within mucosal tissue, ILCs are regulated by complex crosstalk between immune cells and signals received from environmental cues to control infection and restore tissue damage. Here, I will discuss how dysregulation of the ILC response can lead to airway inflammations, such as asthma and COPD (Chronic Obstruction Pulmonary Disease) in humans and experimental models. We have found the dysregulation of the ILC function correlated with the severity and phenotype of diseases. Also, changing the tissue microenvironment affect the sensitivity and features of ILCs. Although many mechanisms and details of the interplay between ILCs and their environment have not yet been elucidated, it is clear that ILCs are a critical player in airway immunity