[대학원 생명과학과 세미나 안내]
연사 : 정태준 교수(부산대학교 생명과학과)
연제 : Plant autophagy as an endomembrane trafficking system
일시 : 2022년 04월 29일 (금) 오후 4시 30분
장소 : 대면 및 온라인 화상 강의로 진행됩니다.
초청교수 : 김옥매 교수
Abstract
Eukaryotic cells have two conserved systems for protein degradation, the ubiquitin-proteasome system and vacuole (or lysosome for metazoans). Degradation of macromolecules in the latter requires elaborate endomembrane trafficking routes. In the endosomal route, plasma membrane and external materials can be imported by endocytosis and sorted into endosomes, which fuse with the vacuole for the degradation of endosomal cargo. Cytoplasmic cargo to be degraded is sequestered by the autophagosome, which similarly fuses with the vacuole. Autophagic pathways are interconnected with the endosomal pathway and other endomembrane trafficking routes, not only because they share common protein and lipid factors but also because their membranes appear to traffic from and to other endomembrane compartments. These confounding features represent one of key challenges for autophagy research. My talk summarizes what we have learned for plant autophagy using Arabidopsis thaliana as a plant model, focusing on the core autophagy machinery and its interaction with the ER via COPII components.