[BK 생명과학과 세미나 안내]
연사 : 임정훈 교수(UNIST)
연제 : Ribosome-associated quality control and translation stress signaling for proteostasis and neural physiology
일시 : 2022년 02월 04일 (금) 오전 11시
장소 : 온라인 화상 강의로 진행됩니다.
초청교수 : 이은진 교수
**Zoom 회의 참가
https://korea-ac-kr.zoom.us/j/89331780922?pwd=WGhhREU2aTRWcDZsbnE4OXpQR0dBZz09
Abstract
Translating ribosomes accompany co-translational regulation of nascent polypeptide chains, including subcellular targeting, protein folding, and covalent modifications. Ribosome-associated quality control (RQC) is a co-translational surveillance mechanism that senses ribosomal collisions during atypical translation and triages aberrant translation intermediates. On the other hand, ribosome-associated kinases GCN2 and ZAKα sense global ribosome collisions induced by ribotoxic stressors, such as translation inhibitors, ribotoxins, and UV radiation, activating integrated stress response (ISR) and ribotoxic stress response (RSR), respectively. The interplay between RQC and the translation stress signaling may sustain proteostasis and determine cell fate since the collided ribosome is their common substrate for activation. In this seminar, I will demonstrate how RQC function contributes to different aspects of neural physiology and discuss how ribosome-associating factors shape the hierarchical crosstalk among RQC, ISR, and RSR pathways.