[대학원 생명과학과 세미나 안내]
연사 : 김윤경 교수(한국과학기술연구원, 뇌과학연구소)
연제 : Tau-BiFC platforms to monitor neurotoxic tau oligomerization in the brain
일시 : 2021년 05월 28일 (금) 오후 5시
장소 : 온라인 화상 강의로 진행됩니다.
초청교수 : 백자현 교수
Abstract
Abnormal tau aggregation is a pathological hallmark in multiple neurodegenerative diseases collectively called tauopathies. Mounting evidences suggest that tau aggregates are only neurotoxic, but also propagate in neurons acting as a seed for native tau aggregation.
Accordingly, prevention of prion-like tau aggregation become an important therapeutic strategy to cure the disease. However, progress has been slow due to the lack of reliable methods to investigate tau pathology. In this regard, we developed a tau-BiFC sensor platform that could monitor and quantify tau aggregation in a living cells and the brain of a mouse. By introducing bimolecular fluorescence complementation (BiFC) technique to tau, we were able to achieve spatial and temporal resolution of tau-tau interactions in a range of states, from soluble dimers to large aggregates. In this presentation, we will introduce the tau-BiFC-sensor models and its various applications to investigating tau pathology.