[대학원 생명과학과 세미나 안내]
연사 : 김경규 교수 (성균관대학교 의과대학)
연제 : Noncanonical DNA: structure, function and implication in gene regulation
일시 : 2020년 9월 11일 (금) 오후 5시
장소 : 온라인 화상 강의로 진행됩니다.
초청교수 : 송현규 교수
Abstract
Most DNA in the genome is considered to be present as a B-form, but number of evidences
support that DNA structures are highly polymorphic. Therefore, many sequence-specific noncanonical
DNA (ncDNA) or non-B-DNA conformations transiently exist in the genome, often in response to
changes in the cellular environment or when bound to proteins. A number of ncDNA structures
including triplexes, hairpin, left-handed DNA, and G-quartet (tetraplexes) are involved in various
cellular events including chromatin remodeling, replication, transcription and recombination, and thus
its presence or mutation is relevant to the various disease including tumors. In addition, it is
verified that many genetic diseases are closely related to ncDNA. Therefore, it is considered that
regulation of ncDNA formation is crucial to understand its cellular function and to develop a novel
strategy for curing the related diseases. In this presentation, current progress of our studies on the
structure, function and modulation of ncDNA will be introduced.