[대학원 생명과학과 세미나 안내]
연사 : 이종봉 교수 (포스텍 물리학과)
연제 : How are distant cells directly connected?
일시 : 2020년 5월 15일 (금) 오후 5시
장소 : 온라인 화상 강의로 진행됩니다.
초청교수 : 우재성 교수
Abstract
In recent decades, intercellular nanotubes (INTs) that connect cells over long distances of up to several cell diameters in vitro have been recognized as a new pathway for long-distance communication between cells. However, it is not yet known how such a fine structure extends over several hundred micrometers and remains robust for several hours. We revealed spatiotemporal processes of INT formation, which is evolved from fine nanostructures of filopodial bridges (two-filopodia complex: DFB). Surprisingly, we have observed DFB helical structures as an intermediate state of single filopodial bridge using super-resolution microscopy and visualized that the helical structure can trigger the transition of the intermediate state to a single filopodial bridge that contacts to the paired cell body via cadherin-cadherin adhesion. Mechanical studies and computer-aided simulations strongly suggest that the transition of DFB into SFB is likely that accumulated torsional energy in DFBs with the helical deformation breaks cadherin-cadherin interactions between two filopodia and the actin retrograde flow of the released filopodium leaves a single bridge attached to a paired cell. The single bridge is strongly supported by cadherin-cadherin clusters at the junction between the end of the bridge and the cell. Our research pinpointed the mechanistic questions in the battle lines.