[대학원 생명과학과 세미나 안내]
연사 : 황철상 교수 (Postech 생명과학과)
연제 : The beginning for the end of proteins
일시 : 2019년 12월 6일 (금) 오후 5시
장소 : 하나과학관 A동 B131호
초청교수 : 이은진 교수
Nα-terminal acetylation (Nt-acetylation) is a predominant modification that occurs largely co-translationally on the vast majority of eukaryotic proteins. However, the general functions of Nt-acetylation are very poorly understood thus far. In 2010, we discovered that Nt-acetylation creates specific protein degradation signals that are targeted by the Ac/N-degron pathway (a part of the ubiquitin-proteasome system). In the first part, I will talk about our recent understanding of the Ac/N-degron pathway that we have studied over the past 10 years.
Most recently, we also found, using the yeast Saccharomyces cerevisiae, that the formyltransferase Fmt1 of this eukaryote, while normally imported into mitochondria, can mediate, in vivo, the synthesis of nuclear DNA-encoded proteins with formyl-methionine (fMet) in the cytosol. In turn, the fMet-bearing proteins can be selectively degraded via a novel eukaryotic fMet/N-degron pathway. In the second part, I want to have a discussion with you about the physiological functions of the fMet-bearing proteins and the fMet/N-degron pathway.